NEW BIOLOGY, NEW THERAPEUTICS
Core Bio reprograms transcription factor networks to reverse disease
A new dimension in transcription factor biology
Transcription factors (TFs) are powerful therapeutic targets that control fundamental cell properties and mechanisms, from cellular identity and differentiation to proliferation and survival. The key to harnessing the power of TFs lies in the fact they operate in hierarchical networks. The Core Bio REPROGRAM AI platform decodes TF networks to specifically identify the TFs that control diseased cells and designs drugs to precisely target those TFs to reprogram the network and reverse disease
TFs operate as hierarchical networks to control gene expression.
Dysregulation of these networks creates deep alterations in gene expression that drive diseases in a programmed manner.
We identify the TFs that control dysregulated networks and block them to reprogram the network and reverse disease.
REPROGRAM AI: From network biology to therapeutic design
Reprogram AI combines advanced computational biology, graph theory, and artificial intelligence to reveal how transcription-factor networks functionally control cell states and disease.
This new dimension of transcription-factor biology enables identifying dominant TFs beyond the reach of current technologies and uncover hidden disease mechanisms.
Built for end-to-end drug discovery, our platform designs TF-modulating medicines to reprogram pathological networks toward therapeutic goals.
